Structural variants of double-stranded DNA: A and Z forms



The A form is a double helix, dextrorse like the B form, but wider. The fictitious line joining the phosphorus atoms defines the trajectory of the backbone; note its helicity.
Note also the inclination of the base pairs, stronger than in B-DNA.

Note that the base pairs are positioned on one side of the helix axis; this is the reason why the helix becomes wider.

Spacefilling model, made of (bases and backbone).
What was the major groove in B-DNA becomes in the A form a narrow and deep groove, while the minor groove is now wide and shallow.

Extension:

The origin of the different conformation of A-DNA


The Z form is a sinistrorse double helix, what makes it different from the A and B forms, and it is thinner. Note how the backbone (fictitious line joining the phosphorus atoms) progresses turning left and in addition makes a zig-zag line. This feature gives the Z form its name.

Spacefilling model, made of (bases and backbone).
What was the major groove in B-DNA becomes in the Z fom a shallow groove, while the minor groove is here narrow and deep.

Extension:

The origin of the different conformation of Z-DNA

Comparison among the A, B and Z forms:

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