Departamento de Química Orgánica

                      

Edificio de Farmacia, Campus Universitario

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Carretera Nacional II, km 33,6
28871 Alcalá  de Henares (Madrid)  
   
   

 

       
       
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Modelos Abióticos de Nucleasas: Publicaciones

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PUBLICACIONES REPRESENTATIVAS

 

     

M.S. Arias, M. González-Álvarez, M.J. Fernández, A. Lorente, G. Alzuet y J. Borrás

“Synthesis and Copper-mediated nuclease activity of a tetracationic tris(2,2’-bipyridine) ligand”

Journal of Inorganic Biochemistry,  2009, 103,1067-1073.

 

Antonio. Lorente y  María José Fernández

Interacciones no covalentes con el ADN

Anales de Química, 2008, 104, 280-289.

 

B. Wilson, M.J. Fernández, A. Lorente y K.B. Grant

“Synthesis and DNA interaction of a bis-phenothiazinium photosensitizer”

Organic and Biomolecular Chemistry, 2008, 6, 4026-4035.

 

M.González-Álvarez, M.S. Arias, M.J. Fernández, L. Gude, A. Lorente, G. Alzuet y J. Borrás

“Copper-mediated DNA photocleavage by a tetrapyridoacridine (tpac) ligand”

Bioorganic and Medicinal Chemistry Letters, 2008, 18, 3286-3290.

 

B. Wilson, M.J. Fernández, A. Lorente y K.B. Grant

“Syntheses and DNA photocleavage by mono- and bis-phenothiazinium-piperazinexylene intercalators”

Tetrahedron, 2008, 64, 3429-3436.

 

M.J. Fernández, B. Wilson, M. Palacios, M.M. Rodrigo, K.B. Grant y A. Lorente

“Copper-Activated DNA Photocleavage by a Pyridine-Linked bis-Acridine Intercalator”

Bioconjugate Chemistry, 2007, 18, 121-129.

 

B. Wilson, L. Gude, M. J. Fernández,  A. Lorente y K. B. Grant

“Tunable DNA Photocleavage by an Acridine-Imidazole Conjugate”

Inorganic Chemistry, 2005, 44, 6159-6173.

 

L. Gude, M. J. Fernández, K. B. Grant y A. Lorente

“Syntheses and Copper(II)-dependent DNA Photocleavage by Acridine and Anthracene 1,10-Phenanthroline

Conjugate Systems”

Organic and Biomolecular Chemistry, 2005, 3, 1856-1862.

 

A. Lorente, Y.G. Vázquez, M.J. Fernández y A. Ferrández

“Bis-Acridines with Aromatic Linking Chains. Synthesis, DNA Interaction and Antitumor Activity”

Bioorganic and Medicinal Chemistry, 2004, 12, 4307-4312.

 

J.-F. Espinosa, M. J. Fernández , K. B. Grant, L. Gude, M.M. Rodrigo y  A. Lorente

“Synthesis, DNA Intercalation and Europium(III)-Triggered DNA Photocleavage by a bis-Proflavine Succinamide Conjugate”

Tetrahedron Letters, 2004, 45, 4017-4020.

 

A. Lorente y  M.J. Fernández

“Modelos Abioticos de Nucleasas: Procesos de Rotura Nucleófila de Ácidos Nucleicos”

Anales de Química, 2002, 24-34.

 

L. Gude, M. J. Fernández, K. B. Grant y  A. Lorente

“DNA Interaction and Photonicking Properties of DNA-Targeted Acridine (2,2’-Bipyridine)Platinum(II) Complexes”

Bioorganic and Medicinal Chemistry Letters, 2002, 12, 3135-3139.

 

L. Gude, M. J. Fernández, K. B. Grant y  A. Lorente

“Anthracene and Naphthalene (2,2’-Bipyridine)Platinum(II) Conjugates: Synthesis and DNA Photocleavage”

Tetrahedron Letters, 2002, 43, 4723-4727.

 

M. J. Fernández, K. B. Grant, F. Herraiz, X. Yang y  A. Lorente

“DNA Photocleavage by Dicationic Bisintercalants”

Tetrahedron Letters, 2001, 42, 5701-5704.

 

M. J. Fernández, L. Gude y  A. Lorente

“An Easy Synthesis of Lepidopterene from 9-Chloromethylanthracene. Evidence for a Free Radical Mechanism”

Tetrahedron Letters, 2001, 42, 891-893.

 

A. Lorente, M. Fernández-Saiz, F. Herraiz, J.-M. Lehn y  J.-P. Vigneron

“Photocleavage of DNA by Tetracationic Intercalands containing Phenazine and Viologen Subunits”

Tetrahedron Letters, 1999, 40, 5901-5904.

 

A. Lorente y M. Casillas

“Syntheses of Imidazo[1,2-c]Pyrimidines and 1,3,5-Triazepines from 2-Azabuta-1,3-Dienes and 1,2-Diamines”

Heterocycles, 1996, 43, 1943-1950.

 

A. Lorente, J. F. Espinosa, M. Fernández-Saiz, J.-M. Lehn, W. D. Wilson y Y. Y. Zhong

“Synthesis of Imidazole-Acridine Conjugates as Ribonuclease A Mimics”

Tetrahedron Letters, 1996, 37, 4417-4420.

 

A. Lorente, M. Casillas, P. Gomez-Sal y  A. Manzanero

“2-Azabuta-1,3-Diene-4-Carbonitriles; Stereoselective Synthesis and Nucleophilic Substitution at the Carbon-Nitrogen Double Bond”

Canadian Journal of Chemistry, 1996, 74, 287-294.

 

A. Lorente, J. L. Alvarez-Barbas, J. L. Soto, P. Gomez-Sal y  A. Manzanero

“On The Mechanism of Formation of Pyridines from a,b-Unsaturated Nitriles and Active Cyano Compounds”

Heterocycles, 1996, 43, 33-47.

 

A. Lorente, C. Galán, I. Fonseca y  J. Sanz-Aparicio

“1-Aminocyclohexene-2,4-Dicarbonitrile Derivatives. Synthesis and Structural Study”

Canadian Journal of Chemistry, 1995, 73, 1546-1555.

 

A. Lorente, M. Fernández-Saiz, J.-M. Lehn y  J.-P. Vigneron

“Cyclo-Bis- and Cyclo-Tris-Intercalands based on Acridine Subunits”

Tetrahedron Letters, 1995, 36, 8279-8282.

 

A. Lorente, M. Fernández-Saiz, J. F. Espinosa, C. Jaime, J.-M. Lehn y  J.-P. Vigneron

“Cyclo-Bis-Intercalands with Acridine Subunits Linked by Rigid Spacers

Tetrahedron Letters, 1995, 36, 5261-5264.

 

                                  

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